Subacute toxicity reports in puppies for four months at 480 mg/kg day-to-day showed no specific changes; at 960 mg/kg, two from 8 died with proof of circulatory collapse. This broad margin of protection is important when compared to chlordiazepoxide HCl, which showed nonspecific changes in six canine at 80 mg/kg.Paradoxical reactions, which include

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